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Breakthroughs in diabetes management

Breakthroughs in diabetes management

Lot of money has been pumped in the research to make the management of diabetes less painful and  better to help in better compliance of medications. People are always curious to know what is new and how they can be better managed. All said and done one must never forget the lifestyle habits which include getting in at least 150 minutes of moderate physical activity, controlling food portions, reducing stress and avoiding smoking and alcohol.

There are a lot of new modalities in sugar checking and monitoring which was detailed in earlier blog. There are some more which are pending patent and approval.

When the sugar levels do not improve with adequate  dose of oral sugar lowering therapies, there were not many options but to start on an injectable therapy. All the new formulations have to prove they are beneficial to the heart and do not harm the heart. This is because heart related problems are the commonest cause of mortality.

There is a class of oral medicine called Sodium Glucose Transporter 2 inhibitor which controls sugar by preventing the re-absorption of glucose by the kidneys. This causes approximately 70 g of glucose to be excreted through the urine. One has to drink more fluids to prevent urinary infection. Dapagliflozin, Empagliflozin and Canagliflozin are available around the world. Canagliflozin is not available in Oman. These are also available in combination with metformin which helps to complement the effect of the medicine. Many are under the impression this is a substitute for insulin and is a wonder drug. This must be carefully used after consultation with the health care provider. This class of medicine must be used only for those with type 2 diabetes.

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As the duration of diabetes advances, the pancreas may not be able to control the sugar levels despite being on maximum tolerable dose of oral sugar lowering medicines. There are times when insulin has to be initiated ( detailed in an earlier blog). Insulin commonly causes weight gain which has been a major point of concern.  There are fixed drug combination which combine a group of medicines called GLP 1 RA which helps to control diabetes by reducing glucagon levels and also help in controlling appetite and thus help in reducing weight and long acting insulin. Xultophy ® combining Liraglutide and Degludec and Soliqua® combining Lixisenatide and Glargine are the available brands. These preparations may have stomach upset and so the dose is titrated gradually.

Xultophysoliqua

The dose has to be adjusted as per the health care providers advice.

There are insulin preparations which work for longer than 24 hours.  Insulin Glargine long acting ( Toujeo® U-300- this means there is 300 units of insulin in cartridge), Insulin Degludec( Tresiba®)

tresibatoujeo

DulaglutideDulaglutide ( Trulicity®) is to be taken once a week which helps reducing the appetite and weight. This belongs to a class of drugs called GLP 1 RA.

There are cholesterol lowering medicines coming in injectable forms which need to be given once in 2 weeks. It is a prefilled singe use syringe. These are expensive and may need to be combined with cholesterol lowering tablets to help reduce the levels. Evolocumab and Alirocumab are the types available in the market.

evolocumabalirocumab

 

Please discuss with the treating doctor regarding the feasibility of using these as part of your treatment regimen.